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Default NMDA receptor antagonist
An NMDA receptor antagonist is a compound in a family of psychoactive drugs, mainly anesthetics, which inhibit (antagonize) the NMDA (N-methyl D-aspartate) receptor. The NMDAR is a glutamate receptor which is responsible for regulating synaptic plasticity and memory.

Legally, there main is role is as both human and animal anesthetics while they can be considered an entheogen for their spiritual use as well as a recreational drug. When used in quantities insufficient for anesthesia, they can cause hallucinogenic, specifically dissociative effects as well as euphoria.

The toxicity of NMDA receptor antagonist varies greatly from substance to substance, as well as with different species. The most common issue cited is the formation of [Olney's lesions], a type of neurotoxic damge, in rodents, though no documented case has been reported within humans.[1]

  1. ^ Anderson, Cliff. "Erowid DXM Vaults : Health : The Bad News Isn't In : A Look at Dissociative-Induced Brain Damage, by Anderson C." Erowid. June 2003. Version 2.2. Web. 18 Aug. 2010.

Created by D-M, 08-18-2010 at 01:42 AM
Last edited by D-M, 08-18-2010 at 01:45 AM
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