Memantine
Memantine is an NMDA receptor antagonist similar to dextromethorphan. It is the first of its class in Alzheimer's medications that target the glutamatergic system. Memantine is marketed under the brands Axura and Akatinol by Merz, Namenda by Forest, Ebixa and Abixa by Lundbeck and Memox by Unipharm. It is occasionally used off-label to treat attention-deficit hyperactivity disorder (ADHD). Its dissociative effect is comparable DXM, with it taking 3-4 times less weight-wise to achieve a similar effect. However, memantine is a low-affinity antagonist and dissociates from the receptor more quickly than DXM. So even in large doses it may not be possible to achieve full dissociation (4th plateau effects). In addition, memantine is a newer compound and less is known about the safety of taking such high doses. While the few recreational reports available mention users taking 50-100mg without apparent physical damage, a user who took a 360mg dose reported lingering mental effects for 5 weeks and flashbacks over 9 months after the experience.
| Memantine molecule |
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