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Default 3-Hydroxymorphinan (3HM)
3-Hydroxymorphinan, or 3HM is a metabolite of Dextromethorphan (DXM) with low toxicity. It is obtained by both CYP2D6 metabolization of 3-Methoxymorphinan (3MM) and CYP3A4 metabolization of Dextrorphan (DXO). 3HM exerts neuroprotective properties by protecting dopamine neurons. Astroglia mediates the 3-HM-induced neurotrophic effect by increasing the gene expression of neurotrophic factors, which is associated with increased acetylation of histone H3. Also, microglia participate in 3-HM-mediated neuroprotection by reducing MPTP-elicited reactive microgliosis.[1]

  1. ^ Zhang, Wei, et al. "3-Hydroxymorphinan, a Metabolite of Dextromethorphan, Protects Nigrostriatal Pathway Against MPTP-Elicited Damage Both in Vivo and in Vitro." FASEB Journal. 20. (2006): 2496-2511.

Contributors: viscosity, jd
Created by viscosity, 04-23-2010 at 10:51 AM
Last edited by jd, 08-29-2010 at 12:24 PM
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