Guaifenesin (gwye-FEN-a-sin) [3-(2-methoxyphenoxy)-1,2-propanediol] is an
expectorant; it increases the production of respiratory tract fluids, thus
making phlegm less viscous and easier to cough up. Guaifenesin has been
shown effective as an expectorant, but is of no use as a cough suppressant.
It is often combined with dextromethorphan. Guaifenesin should not be used
for chronic coughs or coughs accompanied by excessive phlegm (1-2).

High doses of guaifenesin tend to induce emesis (i.e., you puke). Other
effects from high guaifenesin doses are not well known, but probably not
serious. Some suggest that guaifenesin may act as a muscle relaxant at high
doses (an effect for which it is used in veterinary medicine).

Conclusion: as most people do not enjoy vomiting, I would recommend
avoiding guaifenesin-containing products.

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